A Brief Review on the Mechanisms of miRNA Regulation

MicroRNAs (miRNAs) are a class of short,endogenously-initiated non-coding RNAs that post-transcriptionally control gene expression via either translational repression or mRNA degradation.It is becoming evident that miRNAs are play-ing significant roles in regulatory mechanisms operating in various organisms,including developmental timing and host-pathogen interactions as well as cell differentiation,proliferation,apoptosis and tumorigenesis.Likewise,as a regu-latory element,miRNA itself is coordinatively modulated by multifarious effectors when carrying out basic functions,such as SNP,miRNA editing,methylation and circadian clock.This mini-review summarized the current understanding of in-teractions between miRNAs and their targets,including recent advancements in deciphering the regulatory mechanisms that control the biogenesis and functional-ity of miRNAs in various cellular processes.

作 者： Yimei Cai Xiaomin Yu Songnian Hu Jun Yu   作者單位： Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100029,China  刊 名： 基因組蛋白質(zhì)組與生物信息學報（英文版）  英文刊名： GENOMICS、PROTEOMICS & BIOINFORMATICS  年，卷(期)： 2009 7(4)  分類號： Q5  關鍵詞： non-coding RNA   miRNA   miRNA regulation   targets  

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