Crystal Structure and Antitumor Activity of Tri[2- [N-(4′-methyl-benzylsulfonyl)amino]ethyl]-amine

The crystal structure of the title compound (C27H38N4O7S3, Mr = 626.79) has been determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group Pīwith a = 9.411(1), b = 11.645(2), c = 14.672(2) (A。), α = 91.80(1), β = 95.36(1), γ =104.56(1)o, V = 1547.0 (A。)3, Z = 2, Dc = 1.346 g/cm3, λ = 0.71073 (A。), μ(MoKα) = 0.289 mm－1 and F(000) = 664. The structure was refined to R = 0.0406 and wR = 0.1177 for 4103 observed reflections with I > 2σ(I). X-ray diffraction analysis reveals that the title compound is a practically distorted tetrahedron and each molecule contains one lattice H2O by hydrogen bond. The antitumor activity of the title compound against HL-60 human leukemia cells has also been studied by MTT method.

作 者： 臺夕市 尹顯洪 譚民裕 李一志   作者單位： 臺夕市,譚民裕(College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China)

尹顯洪(College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China;Department of Chemistry, Guangxi University for Nationalities, Nanning 530006, China)

李一志(Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China) 

刊 名： 結構化學  ISTIC SCI PKU 英文刊名： CHINESE JOURNAL OF STRUCTURAL CHEMISTRY  年，卷(期)： 2003 22(4)  分類號： O64  關鍵詞： crystal structure   distortion tetrahedron   antitumor activity  

【Crystal Structure and Antitumor Acti】相關文章：

Synthesis and Crystal Structure of a Tetranuclear Cu(Ⅰ) Complex with Vinyfidenebis(diphenylphosphine)04-27

A SAPO-11 Silicoaluminophosphate Molecular Sieve with Stable Crystal Structure04-27

Synthesis and Crystal Structure of Binuclear Copper(Ⅱ)Complex Containing (Dimethylaminomethyl)ferrocene04-27

Crystal Structure of D-Valine at the Temperature of 293, 270, 223 and 173K04-28

Synthesis, Crystal Structure, and Magnetic Properties of a Quasi-one-dimensional Compound Based on TCNQ04-27

Crystal Structure of Derivative of H4-NOBIN and the Applications in Hetero-Diels-Alder Reaction04-27

Synthesis and Crystal Structure of 1,4-Bis(2-hydroxymethylphenyl)-1,4-dioxabutane04-27

Synthesis, Crystal Structure and DNA Interaction of N-(Benzimidazol-2-ylmethyl)-5-chlorosalicylideneimine04-27

Crystal Structure of Natural Non-metamict Ti- and Fe2+-rich Chevkinite-(Ce)04-29

Synthesis and Crystal Structure of 4-Salicyli- deneamino-3-methyl-1,2,4-triazol-5-thione04-28