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Aromatic aldehyde is an important kind of substance for synthesis synthesis of natural products, medical molecules and other materials. Complex molecules can be synthesized by embedding aldehyde to aromatic rings. Extensive research in this field has done. Among others, Reimer-Tiemann reaction is applied comprehensively. Hydroxylate is synthesized in traditional Reimer-Tiemann reaction by alkaline reaction of phenol with chloroform in alcohol solvent. But it is complicated and low in yield.
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