雙酚A對(duì)斑馬魚(yú)胚胎的毒性作用

In order to evaluate the toxicity of the bisphenol A (BPA) on the growth of zebrafish embryos, fertilized eggs were exposed to the concentration of 2.00, 4.00, 6.00, 8.00, 10.00, 15.00, 18.00, 22.00 and 25.00mg/L BPA for72 h at 26± 1 ℃. The results revealed that the sublethal toxicological endpoints induced by BPA were: delayed hatch ＞ blood balk ＞ cyst ＞ altered axial curvature and tail malformation. The median embryo lethal concentration (LC50) after 24 h was 16.36 mg/L. We concluded that the BPA toxicity on zebrafish embryos were caused before 8h exposure and it was not the result of long-term accumulation. Therefore, BPA maybe cause altered gene expression at the early stage of zebrafish embryos. In the further studies, we will use the technology of genetic chips to look for the toxic mechanism of BPA.

作 者： DUAN Zheng-Hua ZHU Lin   作者單位： College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China  刊 名： 水生生物學(xué)報(bào)  ISTIC PKU 英文刊名： ACTA HYDROBIOLOGICA SINICA  年，卷(期)： 2006 30(6)  分類號(hào)： X174  關(guān)鍵詞： Bisphenol A   Zebrafish embryos   Toxicity  

【雙酚A對(duì)斑馬魚(yú)胚胎的毒性作用】相關(guān)文章：

壬基酚和雙酚A對(duì)雄性斑馬魚(yú)(Danio rerio)卵黃蛋白原mRNA的誘導(dǎo)效應(yīng)04-26

雙酚A完全抗原的制備04-26

環(huán)境激素雙酚A與DNA相互作用的電化學(xué)研究04-26

硫代磷酸酯類化合物對(duì)斑馬魚(yú)的急性毒性及QSAR分析04-27

可溶性有機(jī)物對(duì)四溴雙酚A的增溶作用研究04-26

TCDD對(duì)斑馬魚(yú)脂質(zhì)過(guò)氧化作用的初步研究04-26

胺、酚類化合物對(duì)水庫(kù)藻類的慢性毒性研究04-26

微小小環(huán)藻對(duì)雙酚A的富集與降解04-27

β-環(huán)糊精促進(jìn)雙酚A光催化降解04-26

雙酚A的活性污泥法處理特性04-26